clozapine

Clozapine – constipation as an under-recognised life-threatening effect of clozapine

Constipation is an under-recognised life-threatening adverse effect of clozapine.
Clozapine has been associated with varying degrees of impairment of intestinal peristalsis, ranging from constipation to intestinal obstruction, faecal impaction and paralytic ileus. On rare occasions theses cases have been fatal.