Sacubitril valsartan (Entresto®) – Heart failure

NICE have recently published their advice on use of Sacubitril valsartan (Entresto®) for the treatment of symptomatic chronic heart failure with reduced ejection fraction.
Entresto® includes both a neprilysin inhibitor (sacubitril) and an angiotensin II receptor blocker (ARB; valsartan).
The complementary cardiovascular benefits of Entresto in heart failure patients are attributed to the enhancement of peptides that are degraded by neprilysin, such as natriuretic peptides (NP), by LBQ657 and the simultaneous inhibition of the effects of angiotensin II by valsartan.

A reminder about lithium

Lithium is prescribed and monitored in primary care under shared care arrangements. If you are concerned about a patient’s lithium level, renal function or thyroid function, contact the specialist mental health team for advice

Primary Care Responsibilities in Prescribing and Monitoring Hormone Therapy for Transgender and Non-Binary Adults

Transgender and non-binary people will spend a relatively short time under the care of a specialist Gender Identity Clinic. General Practitioners therefore have an important role in the ongoing care of patients when they no longer have a need for specialised gender identity services. The prescribing and monitoring of hormone therapy can be carried out safely in primary care without specialist input, though Gender Identity Clinics are encouraged to provide support to individual General Practitioners when this is requested.

New NICE guidance on controlled drugs

This guideline covers systems and processes for using and managing controlled drugs safely in all NHS settings except care homes. It aims to improve working practices to comply with legislation and have robust governance arrangements. It also aims to reduce the safety risks associated with controlled drugs.

Medication out of stock list

A list of out of stock medication, compiled by Manchester LPC, based on contractor and medicines management feedback contains information on items currently unavailable or hard to obtain.

NHS England launches national programme to combat antibiotic overusage

NHS England has launched the world’s largest healthcare incentive scheme for hospitals, family doctors and other health service providers to […]

Increase to NHS prescription charges from 1st April 2016

From 1st April 2016, NHS prescription charges will increase by 20 pence to £8.40 per item.

Levonorgestrel-releasing intrauterine systems: prescribe by brand name

Levonorgestrel-releasing intrauterine systems should always be prescribed by brand name because products have different indications, durations of use, and introducers.

Nicorandil: reminder of advice for healthcare professionals

Updated advice on use of nicorandil as second-line treatment for stable angina – some ulcers may progress to complications unless treatment is stopped.